26 August 2009

Is your doctor prescribing Celexa?

If he is, you should find a new one. A study published in the Archives of General Psychiatry reveals that the antidepressant Celexa, which doctors sometimes prescribe to children with autism because it has been shown to alleviate repetitive behaviors in individuals with obsessive compulsive disorder, is no more effective than a placebo. Furthermore, the drug puts children at risk for dangerous side effects.

The study was headed by a researcher at Seattle Children's Hospital in conjunction with six other medical centers. 149 children with ASDs enrolled in the study were administered either Celexa (a.k.a. citalopram) or a placebo for twelve weeks. One third of the children taking the antidepressant showed signs of improvement in repetitive behaviors. However, the placebo was shown to be slightly more effective, without the debilitating side effects of dry mouth, shakiness, and drowsiness.

The primary author of the study noted that doctors and parents experimenting with prescriptions may be impressed by the 33% improvement, and may continue the medication inappropriately because it appears to be working. This research shows that there is no scientific evidence of effectiveness, and the use of this medication for ASDs should be discontinued immediately. You can read a summary of the article in the LA Times.

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